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ターゲット

阻害剤

天然化合物

リコンビナントタンパク質

カタログ番号	製品名	別名	ターゲット
T7428	SBI-115		GPCR19
	SBI-115 is an antagonist of TGR5. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5		GPCR19
T4083	BAR501	BAR 501	GPCR19
	BAR501 is an effective and specific GPBAR1 agonist (EC50: 1 μM).		GPCR19
TQ0252	BAR502		FXR , GPCR19 , Autophagy
	BAR502 is a dual GPBAR1 and FXR agonist (IC50s: 0.4 μM and 2 μM).		FXR , GPCR19 , Autophagy
T4352	SB756050	SB-756050,SB 756050	GPCR19
	SB756050 is a specific TGR5 agonist.		GPCR19
T8599	Betazole dihydrochloride	Betazole hydrochloride	Histamine Receptor
	Betazole dihydrochloride (Betazole hydrochloride) is an agonist of H2 receptor.		Histamine Receptor
T11515	Gut restricted-7	GR-7	Potassium Channel
	Gut restricted-7 (GR-7) (GR-7) is a covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. It decreases gut bacterial BSHs and decreases deconjugated bile acid levels in the feces of mice.		Potassium Channel
T1824	TGR5 Receptor Agonist		GPCR19
	TGR5 is a potent TGR5(GPCR19) agonist.		GPCR19
T8818	TC-G 1005		GPCR19
	TC-G 1005 is a potent and selective GPBA agonist (EC50 :0.72 nM; hTGR5). Selective for TGR5 over FXR (farnesoid X receptor). Increases plasma GLP-1 levels and reduces blood glucose in mice. Orally available.		GPCR19
T32873	Maralixibat Chloride	SHP-625,SHP625,Livmarli,LUM001 chloride,Lopixibat chloride,Lopixibat,SHP625 chloride,SHP 625	Potassium Channel
	Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.		Potassium Channel
T35371	Colesevelam Hydrochloride		Others
	Colesevelam Hydrochloride is a bile acid sequestrant with a higher affinity for glycocholic acid in vitro. Colesevelam Hydrochloride inhibits bile acid reabsorption, leading to increased bile acid synthesis and reduces c...		Others
T16376	Odevixibat	A4250	Others
	Odevixibat (A4250) is an effective, selective and orally active ileal bile acid transporter inhibitor. Odevixibat has the potential for the treatment of primary biliary cirrhosis. Odevixibat reduces cholestatic liver and...		Others
T64334	Glycolithocholic acid, sodium salt		Others
	Glycolithocholic acid sodium salt, the sodium form of Glycolithocholic acid, is a glycine-conjugated secondary bile acid utilized in diagnosing ulcerative colitis (UC), non-alcoholic steatohepatitis (NASH), and primary s...		Others
T9154	Sodium taurodeoxycholate hydrate	Taurodeoxycholic acid sodium salt monohydrate	Others
	Sodium taurodeoxycholate hydrate (Taurodeoxycholic acid sodium salt monohydrate) has been used in a study to assess the effect of submicellar concentrations of bile salts on the lipid bilayer membrane.		Others
T11426	Gly-β-MCA		FXR
			FXR
TP1198	Sincalide ammonium	SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium	cholecystokinin
	Sincalide ammonium (CCK-8 ammonium) is a potent analog of the amino acid peptide hormone cholecystokinin (CCK), an active fragment that retains much of the biological activity of CCK.Sincalide ammonium promotes bile secr...		cholecystokinin
T7294	Aramchol	C20-FABAC	Others
	Aramchol (C20-FABAC), also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid. It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholester...		Others
T15209	Elobixibat	AZD 7806,A 3309	Others
	Elobixibat (A 3309) is an inhibitor of the ileal bile acid transporter (IC50: 0.13 nM, 0.53 nM, and 5.8 nM for mouse, human, and canine IBAT). Elobixibat can be used in studies about chronic idiopathic constipation.		Others
T8752	BAR 501 impurity		GPCR19
	BAR501 impurity is an impurity found in the preparation of BAR501 that acts as an agonist of the G protein-coupled bile acid-activated receptor (GP-BAR1). BAR501 impurity (10 μM) induces a 150% increase in luciferase act...		GPCR19
T32420	Kryptogenin	Cryptogenine,Cryptogenin
	Kryptogenin, derived from carp bile, can be used to synthesize C27-intermediates in bile acid biosynthesis.
T37771	Taurolithocholic Acid 3-sulfate (sodium salt)
	Taurolithocholic acid 3-sulfate (TLCA3S) is a metabolite of the conjugated bile acid taurolithocholic acid . TLCA3S has been used to study bile acid transport in cellular models and to induce pancreatitis in mouse models...
T30270	Azidobenzamidotaurocholate
	Azido Benzamido Taurocholate is a bile acid transporter.
T27015	Cicrotoic acid
	Cicrotoic acid, a biochemical drug, acts on bile flow and liquid composition of human bile.
TMIH-0257	Glycoursodeoxycholic Acid-d4
	Glycoursodeoxycholic Acid-d4 is a deuterated compound of Glycoursodeoxycholic Acid. Glycoursodeoxycholic Acid has a CAS number of 64480-66-6. Glycoursodeoxycholic acid is an acyl glycine and a bile acid-glycine conjugate...
T13622	Cholestyramine	Colestyramine,Cholestyramine resin	Others
	Cholestyramine (Cholestyramine resin), a bile acid-binding resin, inhibits intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol.		Others
T69558	Barixibat
	Barixibat is a bile acid transport inhibitor.
T2968L	Hyodeoxycholic acid sodium salt	Sodium hyodeoxycholate,HDCA sodium
	Hyodeoxycholic acid sodium salt is a natural secondary bile acid. It improves high-density lipoprotein function, reduces farnesoid X receptor antagonist bile acids, and induces strong cytotoxicity, apoptosis, and IL-8 sy...
T32797	Lithocholenic acid
	Lithocholenic acid is a bile acid that acts as a detergent to solubilize fats for absorption.
T16818	S-8921		Others
	S-8921 is an inhibitor of ileal Na+/bile acid cotransporter.		Others
T28700	SC-435 mesylate	SC-435,SC435,SC 435
	SC-435 is an ileal apical sodium co-dependent bile acid transporter (ASBT). SC-435 inhibits plasma cholesterol.
T70688	S 0960
	S 0960 is a dimeric bile acid analogue that acts as a specific inhibitor of the apical sodium-dependent bile salt transporter (ASBT) in the ileum.
T37845	Taurocholic Acid 3-sulfate (sodium salt)
	Taurocholic acid 3-sulfate (TCA3S) is a metabolite of the conjugated bile acid taurocholic acid .1Plasma levels of TCA3S are elevated in wild-type andSortilin 1(Sort1) knockout mice at 6 hours following bile duct ligatio...
T37178	Norhyodeoxycholic Acid
	Norhyodeoxycholic acid (NHDCA) is a synthetic bile acid and a derivative of hyodeoxycholic acid .1,2 NHDCA is an intermediate in the synthesis of 3β-sulfooxy-7β-hydroxy-24-nor-5-cholen-23-oic acid, which has been used as...
T17236	Volixibat	SHP626,LUM002	Others
	Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis.		Others
T10090	264W94		Others
			Others
T69622	Ritivixibat
	Ritivixibat is an ileal bile acid transporter (IBAT) inhibitor and bile acid modulator. It is utilized in research related to cardiovascular diseases, fatty acid metabolism disorders, glucose utilization abnormalities, g...
T75599	Glycodehydrocholic acid
	Glycodehydrocholic acid, a bile acid glycine conjugate, is employed in the diagnosis of cancer and various diseases [1] [2].
T36075	Cholic Acid anilide
	Cholic acid anilide is a synthetic bile acid and derivative of cholic acid that inhibits the germination of C. difficile strain R20291 spores in vitro (IC50 = 1.8 μM).1 \|1. Sharma, S.K., Yip, C., Esposito, E.X., et al. T...
T37798	Petromyzonol
	Petromyzonol is a tetrahydroxy stearol which serves as the primary spawning pheromone in adult sea lamprey. It is produced in the bile of sea lamprey larvae from the bile acid precursor allocholic acid. While the adult s...
T83900	12β-Hydroxyisocholic Acid	LCA,Lagocholic Acid
	12β-Hydroxyisocholic acid, a bile acid and an isomer of cholic acid, exhibits increased hepatic levels in a mouse model of alcoholic liver damage.
T37416	Tauro-α-muricholic Acid (sodium salt)
	Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid . TαMCA is common in rodents but h...
T36522	Isoallolithocholic acid	Alloisolithocholic Acid,AILCA,3β-Hydroxy-5α-cholanic acid	Others
	Isoallolithocholic acid (3β-Hydroxy-5α-cholanic acid) is a T-cell modulator, a bile acid metabolite with anti-inflammatory activity that is associated with human immune homeostasis.		Others
T36132	3β-OH-7-Oxocholenic Acid
	3β-OH-7-Oxocholenic acid is a bile acid.1 It is also a metabolite of 7β-hydroxy cholesterol in rats. Conjugated forms of 3β-OH-7-oxocholenic acid have been found in the urine of patients with Neimann-Pick disease type C....
T37854	Cholic Acid 7-sulfate
	Cholic acid 7-sulfate is a metabolite of the primary bile acid cholic acid.[1],[2] It is produced by conjugation of a sulfate group with the hydroxy group at position 7 of cholic acid in the liver and gut. Fecal levels o...
T37846	Taurohyocholic Acid (sodium salt)
	Taurohyocholic acid (THCA) is a taurine-conjugated form of the porcine-specific primary bile acid hyocholic acid .1THCA inhibits precipitation of cholesterol crystals by stabilizing cholesterol in the liquid-crystalline ...
TMIH-0552	Tauroursodeoxycholic Acid-d4 Sodium Salt
	Tauroursodeoxycholic Acid-d4 Sodium Salt is a deuterated compound of Tauroursodeoxycholic Acid Sodium Salt. Tauroursodeoxycholic Acid Sodium Salt has a CAS number of 14605-22-2. Tauroursodeoxycholate, also known as ursod...
T63793	Tauro-ω-muricholic acid sodium
	Tauro-ω-muricholic acid sodium (TωMCA sodium) is an analogue of tauro-α-muricholic acid, a bile acid of hepatic origin. Tauro-ω-muricholic acid sodium can be used as a serum marker for early onset neonatal sepsis (EOS) a...
T37251	Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide
	Celecoxib carboxylic acid acyl-β-D-glucuronide is a phase II metabolite of celecoxib . Celecoxib is an anti-inflammatory compound from the diaryl heterocycle class that selectively inhibits cyclooxygenase-2 (COX-2; IC50s...
T81000	TGR5 Receptor Agonist 4
	TGR5 Receptor Agonist 4, a selective agonist for the Bile Acid Receptor (TGR5), exhibits potent activity with an EC50 of 2 nM for human TGR5 (hTGR5) and 3 nM for mouse TGR5 (mTGR5). It is notably involved in mediating hy...
T37666	Trihydroxycholestanoic Acid	Trihydroxycoprostanic Acid
	Trihydroxycholestanoic acid is an intermediate in the biosynthesis of cholic acid .1 Elevated plasma levels of trihydroxycholestanoic acid have been found in patients with Zellweger syndrome, a neurological disorder char...
T10447	BAA473		Others
	BAA473 is a bile acid analog that is a potent activator of the pyrin inflammasome. BAA473 can induce secretion of interleukin-18 (IL-18) through activation of the inflammasome in both myeloid and intestinal epithelial c...		Others

Compounds

Target: FXR, GPCR19, Autophagy

SB756050

T4352

Synonym: SB-756050,SB 756050

Target: GPCR19

Betazole dihydrochloride

T8599

Synonym: Betazole hydrochloride

Target: Histamine Receptor

Gut restricted-7

T11515

Synonym: GR-7

Target: Potassium Channel

TGR5 Receptor Agonist

Synonym: SHP-625,SHP625,Livmarli,LUM001 chloride,Lopixibat chloride,Lopixibat,SHP625 chloride,SHP 625

Target: Potassium Channel

Colesevelam Hydrochloride

Glycolithocholic acid, sodium salt

T64334

Synonym:

Target: Others

Sodium taurodeoxycholate hydrate

T9154

Synonym: Taurodeoxycholic acid sodium salt monohydrate

Synonym: SQ19844 ammonium,CCK-8 ammonium,Cholecystokinin octapeptide ammonium

Target: cholecystokinin

Synonym: AZD 7806,A 3309

Synonym: Cryptogenine,Cryptogenin

Target:

Taurolithocholic Acid 3-sulfate (sodium salt)

T37771

Synonym:

Target:

Azidobenzamidotaurocholate

Glycoursodeoxycholic Acid-d4

Synonym: Colestyramine,Cholestyramine resin

Hyodeoxycholic acid sodium salt

T2968L

Synonym: Sodium hyodeoxycholate,HDCA sodium

Synonym: SC-435,SC435,SC 435

Taurocholic Acid 3-sulfate (sodium salt)

T37845

Synonym:

Target:

Norhyodeoxycholic Acid

Synonym: SHP626,LUM002

Glycodehydrocholic acid

T75599

Synonym:

Target:

Cholic Acid anilide

12β-Hydroxyisocholic Acid

T83900

Synonym: LCA,Lagocholic Acid

Target:

Tauro-α-muricholic Acid (sodium salt)

T37416

Synonym:

Target:

Isoallolithocholic acid

T36522

Synonym: Alloisolithocholic Acid,AILCA,3β-Hydroxy-5α-cholanic acid

Target: Others

3β-OH-7-Oxocholenic Acid

T36132

Synonym:

Target:

Cholic Acid 7-sulfate

T37854

Synonym:

Target:

Taurohyocholic Acid (sodium salt)

T37846

Synonym:

Target:

Tauroursodeoxycholic Acid-d4 Sodium Salt

TMIH-0552

Synonym:

Target:

Tauro-ω-muricholic acid sodium

T63793

Synonym:

Target:

Celecoxib Carboxylic Acid Acyl-β-D-Glucuronide

T37251

Synonym:

Target:

TGR5 Receptor Agonist 4

T81000

Synonym:

Target:

Trihydroxycholestanoic Acid

T37666

Synonym: Trihydroxycoprostanic Acid

カタログ番号	製品名	別名	ターゲット
T2965	Deoxycholic acid	Cholorebic,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic	Endogenous Metabolite , GPCR19
	Deoxycholic acid (Cholanoic Acid) is a bile acid formed by bacterial action from cholate. It is usually conjugated with glycine or taurine. Deoxycholic acid acts as a detergent to solubilize fats for intestinal absorptio...		Endogenous Metabolite , GPCR19
T5077	Deoxycholic acid sodium salt	Sodium deoxycholate,Sodium Desoxycholate	Endogenous Metabolite , GPCR19
	Deoxycholic acid sodium salt (Sodium deoxycholate) can activate the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.		Endogenous Metabolite , GPCR19
T8153	Glycohyodeoxycholic acid		Others , Endogenous Metabolite
	glycohyodeoxycholic acid is a major metabolite of the secondary bile acid hyodeoxycholic acid in humans.		Others , Endogenous Metabolite
T19189	Allocholic acid		Others
	Allocholic acid is a fetal bile acid found in vertebrates and reappears during liver regeneration and carcinogenesis. It is also a potent and specific stimulant of the adult olfactory system.		Others
T0700	Ursodeoxycholic acid	UDCA,Ursodiol	Potassium Channel , Endogenous Metabolite
	Ursodeoxycholic acid (UDCA) can be used to dissolve gallstones and reduce cholesterol absorption.		Potassium Channel , Endogenous Metabolite
T0022	Taurine	2-Aminoethanesulfonic acid	LDL , Endogenous Metabolite , Autophagy
	Taurine (2-Aminoethanesulfonic acid), an organic acid, is distributed in various animal tissues.		LDL , Endogenous Metabolite , Autophagy
T31964	Glycolithocholic acid	Lithocholic acid glycine conjugate,Lithocholylglycine	Others
	Glycolithocholic acid (Lithocholic acid glycine conjugate) is a glycine conjugate of lithocholic acid.		Others
T13502	3-Oxo-5β-cholanoic acid	Dehydrolithocholic acid	ROR
			ROR
T29078	Ursodeoxycholic acid sodium	UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium	FXR , Endogenous Metabolite , GPCR19
	Ursodeoxycholic acid sodium (Sodium Ursodeoxycholate) is a naturally occurring secondary bile acid with anti-inflammatory and cytoprotective activities. Ursodeoxycholic acid sodium acts as signaling molecule, exerting it...		FXR , Endogenous Metabolite , GPCR19
T13522	7-Ketolithocholic acid	3α-Hydroxy-7-oxo-5β-cholanic acid	Endogenous Metabolite
	7-Ketolithocholic acid (3α-Hydroxy-7-oxo-5β-cholanic acid) (3α-Hydroxy-7-oxo-5β-cholanic acid) is capable of absorption and serves to suppress the production of endogenous bile acid and the secretion of biliary cholester...		Endogenous Metabolite
T2968	Hyodeoxycholic acid	NSC 60672,α-Hyodeoxycholic Acid,HDCA	FXR , Endogenous Metabolite , GPCR19
	Hyodeoxycholic acid (NSC 60672) has been used in trials studying the treatment of Hypercholesterolemia.		FXR , Endogenous Metabolite , GPCR19
T2A2481	Taurochenodeoxycholic Acid	Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine	Apoptosis , TNF , Caspase , Endogenous Metabolite
	Taurochenodeoxycholic Acid (12-Deoxycholyltaurine) is one of the main bioactive substances of animals' bile acid.		Apoptosis , TNF , Caspase , Endogenous Metabolite
TN2215	Taurochenodeoxycholic acid sodium	Sodium taurochenodeoxycholate	Apoptosis , Endogenous Metabolite
	Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) is one of the main bioactive substances of animals' bile acid. Taurochenodeoxycholic acid sodium induces apoptosis and shows obvious anti-inflammatory and...		Apoptosis , Endogenous Metabolite
T5234	Glycoursodeoxycholic acid	Ursodeoxycholylglycine,GUDCA	Others , Endogenous Metabolite
	Glycoursodeoxycholic acid (Ursodeoxycholylglycine) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic enviro...		Others , Endogenous Metabolite
T19124	3-Oxocholic acid	3-Ketocholic acid	Endogenous Metabolite
	3-Oxocholic acid(3-Ketocholic acid) is the metabolite of bile acid and the main product of bile degradation by Clostridium perfringens in the intestine.3-Oxocholic acid is a steroid acid mainly found in the bile of mamma...		Endogenous Metabolite
T0516	Dehydrocholate sodium	Sodium dehydrocholate	Endogenous Metabolite , Lipid
	Dehydrocholate sodium, a hydrocholeretic, can increase bile output to clear increased bile acid load.		Endogenous Metabolite , Lipid
T7331	Ursocholic acid		Endogenous Metabolite
	Ursocholic acid, a bile acid found predominantly in bile of mammals.		Endogenous Metabolite
T5259	Glycochenodeoxycholic acid sodium salt	GCDCA,Sodium glycochenodeoxycholate	Apoptosis , Others , Endogenous Metabolite
	Glycochenodeoxycholic acid sodium salt (GCDCA) is an acyl glycine and a bile acid-glycine conjugate. It is a secondary bile acid produced by the action of enzymes existing in the microbial flora of the colonic environmen...		Apoptosis , Others , Endogenous Metabolite
T5352	GLYCODEOXYCHOLIC ACID		Others , Endogenous Metabolite
	Glycodeoxycholic Acid is a bile acid that induces severe pancreatitis in rats. It can induce the apoptosis of SMMC-7721 cells.		Others , Endogenous Metabolite
T5072	Glycocholic acid hydrate		Others , Endogenous Metabolite
	Glycocholic Acid is the product of conjugation of cholic acid with glycine. It is the chief ingredient of the bile of herbivorous animals.		Others , Endogenous Metabolite
T7628	3b-Hydroxy-5-cholenoic acid		Endogenous Metabolite
	3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin		Endogenous Metabolite
TJA2398	Taurodeoxycholic acid sodium hydrate	Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt	Apoptosis , Caspase
	Taurodeoxycholic acid sodium hydrate (Sodium taurodeoxycholate monohydrate), a hydrophilic bile salt, on bile salt and biliary lipid secretion in the rat.		Apoptosis , Caspase
T14002	12-Ketodeoxycholic acid		Endogenous Metabolite
	12-Ketodeoxycholic acid, a bile acid and kidney metabolite, serves as a detectable marker for kidney injury [1].		Endogenous Metabolite
T0408	Dehydrocholic acid	Dehystolin,Felacrinos,Sanocholen,Decholin	Others
	Dehydrocholic acid (Dehystolin) is a synthetic bile acid, produced by the oxidation of cholic acid.		Others
T35792	Isolithocholic Acid	3-Epilithocholic acid,3β-Hydroxy-5β-cholanic acid,β-Lithocholic acid,isoLCA	Endogenous Metabolite
	Isolithocholic Acid (3-Epilithocholic acid) (β-Lithocholic acid) is an isomer of Lithocholic acid. Isolithocholic Acid, a bile acid, is formed by microbial metabolism of Lithocholic acid or Lithocholic acid 3α-sulfate.		Endogenous Metabolite
T2831	Glycocholic acid	Glycocholate,cholylglycine	Others , Endogenous Metabolite
	Glycocholic acid (Glycocholate) is a bile acid with anticancer activity. Glycocholic acid targets against pump resistance-related and non-pump resistance-related pathways.		Others , Endogenous Metabolite
T2963	Cholic Acid	Cholanic acid,Cholate,Colalin	Endogenous Metabolite
	Cholic Acid (Cholate) is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. Cholic acid facilitates fat absorption and cholesterol excretion.		Endogenous Metabolite
T37997	Murideoxycholic Acid
	Murideoxycholic acid (MDCA) is a secondary bile acid produced from α-muricholic acid and β-muricholic acid.[1] It is also a metabolite of lithocholic acid in liver S9 fractions from humans and other species.[2] MDCA prev...
T2744	Methyl Cholate	Cholic acid methyl ester	Others
	Methyl Cholate (Cholic acid methyl ester) is the methyl form of cholic acid. Cholic acid is a major bile acid produced by the liver and synthesized from cholesterol.		Others
T4727	Taurolithocholic acid sodium salt	Sodium taurolithocholate	Others , Calcium Channel
	Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, but not to M2 or M3 receptors.		Others , Calcium Channel
T4070	Glycocholic Acid Sodium Salt	Glycocholate Sodium,Sodium Glycocholate	Others
	Glycocholic Acid Sodium Salt (Sodium Glycocholate) is a conjugated bile salt and ionic biologic detergent. It is involved in the emulsification of fats.		Others
T2532	Tauroursodeoxycholate	Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA	Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
	Tauroursodeoxycholate (UR 906), also known as ursodoxicoltaurine, is a highly hydrophilic tertiary bile acid that is produced in humans at a low concentration. Tauroursodeoxycholate is the more hydrophilic form of ursode...		Apoptosis , ERK , P450 , Caspase , Endogenous Metabolite
TN2259	Taurocholic acid	N-Choloyltaurine	TNF , PI3K
	Taurocholic acid (N-Choloyltaurine) is a bile acid involved in the emulsification of fats.Taurocholic acid is cytoprotective, preventing tumor necrosis factor-alpha-induced cholangiocyte damage via a PI3K-mediated pathwa...		TNF , PI3K
T4588	Glycochenodeoxycholic Acid	Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine	Apoptosis , Endogenous Metabolite
	Glycochenodeoxycholic Acid (Lithocholylglycine) is a glycine conjugate of lithocholic acid, a bile acid. It is increased in livers of mice that are fed diets supplemented with ursadeoxycholic acid. Glycolithocholic acid ...		Apoptosis , Endogenous Metabolite
T13506	3β-Ursodeoxycholic acid	Isoursodeoxycholic acid
	3β-Ursodeoxycholic acid (Isoursodeoxycholic acid) is a bile acid. 3β-Ursodeoxycholic acid (administered orally has shown good tolerability and good intestinal absorption. 3β-Ursodeoxycholic acid can undergo enzymatic iso...
T1138	Taurocholic acid sodium salt hydrate	Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate	Others , Potassium Channel , Endogenous Metabolite
	Taurocholic acid sodium salt hydrate (Sodium taurocholate hydrate) is the product of conjugation of taurine with cholic acid. The sodium salt, the main ingredient of the bile of carnivorous animals, is used as a detergen...		Others , Potassium Channel , Endogenous Metabolite
TWA2417	Sodium taurocholate	Taurocholate Sodium	Others
	Sodium taurocholate (Taurocholate Sodium) hydrate is the main end product of cholesterol catabolism. During enterohepatic circulation, bile taurocholic acid is converted by the microorganisms to taurodeoxycholic acid and...		Others
T2202	Lithocholic acid	3α-Hydroxy-5β-cholanic acid	Apoptosis , Others , FXR , Endogenous Metabolite , Autophagy
	Lithocholic acid (3α-Hydroxy-5β-cholanic acid) is a bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is...
T5254	Glycodeoxycholate Sodium	Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt	Others , Endogenous Metabolite
	Glycodeoxycholate Sodium (Glycodeoxycholic acid sodium salt) induces Apoptosis in hepatocytes by a mechanism associated with DNA cleavage by endonucleases. It is a secondary bile acid produced by the action of enzymes ex...		Others , Endogenous Metabolite
T0847	Chenodeoxycholic acid	CDCA,Chenodiol	Potassium Channel , FXR , Endogenous Metabolite , Autophagy
	Chenodeoxycholic acid (CDCA) is a bile acid, usually conjugated with either glycine or taurine. It acts as a detergent to solubilize fats for intestinal absorption and is reabsorbed by the small intestine. It is used as ...		Potassium Channel , FXR , Endogenous Metabolite , Autophagy
T75319	Taurodeoxycholic acid	Taurodeoxychloic acid	Apoptosis , Calcium Channel , Caspase
	Taurodeoxycholic acid (Taurodeoxychloic acid) is a bile acid taurine conjugate of deoxycholic acid, a human metabolite that stabilizes mitochondrial membranes and reduces the formation of free radicals.Taurodeoxycholic a...		Apoptosis , Calcium Channel , Caspase
T15245	Erythromycin estolate	Phtalic anhydride,ilosone	Antibacterial
	Erythromycin estolate is a derivative of erythromycin, which belongs to the macrolide class of antibiotics and is often used to study a variety of bacterial infections. Erythromycin estolate has an inhibitory effect on b...		Antibacterial
TJO2758	D-Glucuronic acid	Aldehydo-D-Glucuronic Acid	Others , Endogenous Metabolite
	D-Glucuronic acid (Aldehydo-D-Glucuronic Acid) is a carboxylic acid with structural similarity to glucose with detoxifying activity. The xenobiotic metabolism of various substances such as drugs, pollutants, bilirubin, a...		Others , Endogenous Metabolite
TN6909	Polyporusterone B	(1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one	Others
	Polyporusterone B ((1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one) is a triterpene carboxylic aci...		Others
T36585	Isodeoxycholic Acid	isoDCA	Chloride channel , Antibacterial
	Isodeoxycholic Acid is a bile acid that is formed via epimerization of deoxycholic acid by intestinal bacteria. It has a greater critical micelle concentration than DCA, indicating reduced detergent activity, and is less...		Chloride channel , Antibacterial
T19623	α-Muricholic acid		AChR
	α-Muricholic acid is the most abundant primary bile acid in rodents.		AChR
T40790	ω-Muricholic Acid
	ω-Muricholic acid (ω-MCA) is a murine-specific secondary bile acid.
T13505	3α,12β-Dihydroxycholanoic acid		Others
	3α,12β-Dihydroxycholanoic acid, a bile acid, can be isolated from urine specimens of healthy humans.		Others
T10196	7α-Hydroxy-4-cholesten-3-one		Others
			Others
T81030	Tauro-β-muricholic acid	TβMCA	FXR
	Tauro-β-muricholic acid (TβMCA), a trihydroxylated bile acid, acts as a competitive and reversible FXR antagonist (IC 50 = 40 μM) and exhibits antiapoptotic effects by inhibiting bile acid-induced hepatocellular apoptosi...		FXR
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天然物製品

Deoxycholic acid

T2965

Synonym: Cholorebic,Deoxycholate,Desoxycholic acid,Cholanoic Acid,Cholerebic

Target: Endogenous Metabolite, GPCR19

Deoxycholic acid sodium salt

T5077

Synonym: Sodium deoxycholate,Sodium Desoxycholate

Target: Endogenous Metabolite, GPCR19

glycohyodeoxycholic acid

T8153

Synonym:

Target: Others, Endogenous Metabolite

Ursodeoxycholic acid

T0700

Synonym: UDCA,Ursodiol

Target: Potassium Channel, Endogenous Metabolite

Taurine

T0022

Synonym: 2-Aminoethanesulfonic acid

Target: LDL, Endogenous Metabolite, Autophagy

Glycolithocholic acid

T31964

Synonym: Lithocholic acid glycine conjugate,Lithocholylglycine

Target: Others

3-Oxo-5β-cholanoic acid

T13502

Synonym: Dehydrolithocholic acid

Target: ROR

Ursodeoxycholic acid sodium

T29078

Synonym: UDCA Na,UDCA sodium,Sodium Ursodeoxycholate,Ursodiol sodium,Ursodeoxycholic Acid (sodium salt),Ursodeoxycholate sodium

Target: FXR, Endogenous Metabolite, GPCR19

7-Ketolithocholic acid

T13522

Synonym: 3α-Hydroxy-7-oxo-5β-cholanic acid

Target: Endogenous Metabolite

Hyodeoxycholic acid

T2968

Synonym: NSC 60672,α-Hyodeoxycholic Acid,HDCA

Target: FXR, Endogenous Metabolite, GPCR19

Taurochenodeoxycholic Acid

T2A2481

Synonym: Chenodeoxycholyltaurine,TCDCA,Chenyltaurine,Taurochenodeoxycholate,12-Deoxycholyltaurine

Target: Apoptosis, TNF, Caspase, Endogenous Metabolite

Taurochenodeoxycholic acid sodium

TN2215

Synonym: Sodium taurochenodeoxycholate

Target: Apoptosis, Endogenous Metabolite

Glycoursodeoxycholic acid

T5234

Synonym: Ursodeoxycholylglycine,GUDCA

Target: Others, Endogenous Metabolite

3-Oxocholic acid

T19124

Synonym: 3-Ketocholic acid

Target: Endogenous Metabolite

Dehydrocholate sodium

T0516

Synonym: Sodium dehydrocholate

Target: Endogenous Metabolite, Lipid

Ursocholic acid

T7331

Synonym:

Target: Endogenous Metabolite

Glycochenodeoxycholic acid sodium salt

T5259

Synonym: GCDCA,Sodium glycochenodeoxycholate

Target: Apoptosis, Others, Endogenous Metabolite

GLYCODEOXYCHOLIC ACID

T5352

Synonym:

Target: Others, Endogenous Metabolite

Glycocholic acid hydrate

T5072

Synonym:

Target: Others, Endogenous Metabolite

3b-Hydroxy-5-cholenoic acid

T7628

Synonym:

Target: Endogenous Metabolite

Taurodeoxycholic acid sodium hydrate

TJA2398

Synonym: Sodium taurodeoxycholate monohydrate,Taurodeoxychloic Acid sodium hydrate,Taurohyodeoxycholic acid sodium salt

Target: Apoptosis, Caspase

12-Ketodeoxycholic acid

T14002

Synonym:

Target: Endogenous Metabolite

Dehydrocholic acid

T0408

Synonym: Dehystolin,Felacrinos,Sanocholen,Decholin

Target: Others

Isolithocholic Acid

T35792

Synonym: 3-Epilithocholic acid,3β-Hydroxy-5β-cholanic acid,β-Lithocholic acid,isoLCA

Target: Endogenous Metabolite

Glycocholic acid

T2831

Synonym: Glycocholate,cholylglycine

Target: Others, Endogenous Metabolite

Cholic Acid

T2963

Synonym: Cholanic acid,Cholate,Colalin

Target: Endogenous Metabolite

Murideoxycholic Acid

Synonym: Cholic acid methyl ester

Target: Others

Taurolithocholic acid sodium salt

T4727

Synonym: Sodium taurolithocholate

Target: Others, Calcium Channel

Glycocholic Acid Sodium Salt

T4070

Synonym: Glycocholate Sodium,Sodium Glycocholate

Target: Others

Tauroursodeoxycholate

T2532

Synonym: Taurolite,Tauroursodeoxycholic Acid,UR 906,Ursodeoxycholyltaurine,TUDCA

Target: Apoptosis, ERK, P450, Caspase, Endogenous Metabolite

Taurocholic acid

TN2259

Synonym: N-Choloyltaurine

Target: TNF, PI3K

Glycochenodeoxycholic Acid

T4588

Synonym: Glycine chenodeoxycholate,Chenodeoxycholylglycine,GCDCA,Glycochenodeoxycholate,Lithocholylglycine

Target: Apoptosis, Endogenous Metabolite

3β-Ursodeoxycholic acid

T13506

Synonym: Isoursodeoxycholic acid

Target:

Taurocholic acid sodium salt hydrate

T1138

Synonym: Sodium taurocholate hydrate,Taurocholic Acid sodium hydrate

Target: Others, Potassium Channel, Endogenous Metabolite

Sodium taurocholate

TWA2417

Synonym: Taurocholate Sodium

Target: Others

Lithocholic acid

T2202

Synonym: 3α-Hydroxy-5β-cholanic acid

Target: Apoptosis, Others, FXR, Endogenous Metabolite, Autophagy

Glycodeoxycholate Sodium

T5254

Synonym: Sodium glycyldeoxycholate,Sodium glycodeoxycholate,Glycodeoxycholic acid sodium salt

Target: Others, Endogenous Metabolite

Chenodeoxycholic acid

T0847

Synonym: CDCA,Chenodiol

Target: Potassium Channel, FXR, Endogenous Metabolite, Autophagy

Taurodeoxycholic acid

T75319

Synonym: Taurodeoxychloic acid

Target: Apoptosis, Calcium Channel, Caspase

Erythromycin estolate

T15245

Synonym: Phtalic anhydride,ilosone

Target: Antibacterial

D-Glucuronic acid

TJO2758

Synonym: Aldehydo-D-Glucuronic Acid

Target: Others, Endogenous Metabolite

Polyporusterone B

TN6909

Synonym: (1R,2R,4S,5R,7R,11R,14S,15R)-14-[(2R,3R)-2,3-dihydroxy-6-methyl-5-methylideneheptan-2-yl]-4,5,11-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,?.011,1?]heptadec-9-en-8-one

Target: Others

Isodeoxycholic Acid

T36585

Synonym: isoDCA

Target: Chloride channel, Antibacterial

3α,12β-Dihydroxycholanoic acid

T13505

Synonym:

Target: Others

7α-Hydroxy-4-cholesten-3-one

T10196

Synonym:

Target: Others

Tauro-β-muricholic acid

T81030

Synonym: TβMCA

Target: FXR

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Recombinant Proteins

Species：

Expression System：

Tag：

カタログ番号	製品名	Species	Expression System
TMPJ-00529	FABP6 Protein, Human, Recombinant (His)	Human	E. coli
	Fatty Acid-Binding Protein 6 (FABP6) is cytoplasmic protein that binds long-chain fatty acids and other hydrophobic ligands which belongs to the calycin superfamily. FABP6 expression is restricted in the small intestine ...
TMPJ-00207	AKR1C2 Protein, Human, Recombinant	Human	E. coli
	Aldo-Keto Reductase Family 1 Member C2 (AKR1C2) plays a role in concert with the 5-α/5-β-Steroid Reductases to convert Steroid hormones into the 3-α/5-α and 3-α/5-β-Tetrahydrosteroids. AKR1C2 catalyzes the inactivation o...
TMPY-02907	FGF-19 Protein, Human, Recombinant	Human	E. coli
	FGF19, also known as FGF-19, is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inclu...
TMPH-02652	FGF-15 Protein, Mouse, Recombinant (His & SUMO)	Mouse	E. coli
	Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression.
TMPY-02249	FABP6 Protein, Human, Recombinant	Human	E. coli
	Gastrotropin, also known as Fatty acid-binding protein 6, Ileal lipid-binding protein, ILBP, Intestinal 15 kDa protein, Intestinal bile acid-binding protein, I-BABP and FABP6, is a cytoplasm protein which belongs to t...
TMPH-02681	GPX7 Protein, Mouse, Recombinant (His & Myc)	Mouse	E. coli
	It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks. G...
TMPH-00721	YgiS Protein, E. coli, Recombinant (His & SUMO)	E. coli	E. coli
	Probably part of a deoxycholate transport system. Its expression in the presence of deoxycholate in a ygiS deletion mutant increases intracellular deoxycholate levels and decreases cell growth; higher expression in the p...
TMPY-00481	AKR1C4 Protein, Human, Recombinant (His)	Human	E. coli
	Aldo-keto reductases comprise of AKR1C1-AKR1C4, four enzymes that catalyze NADPH dependent reductions and have been implicated in biosynthesis, intermediary metabolism, and detoxification. there is a strong correlation ...
TMPY-01878	L-FABP Protein, Human, Recombinant (His)	Human	E. coli
	Fatty acid-binding protein, liver, also known as Fatty acid-binding protein 1, Liver-type fatty acid-binding protein, FABP1 and FABPL,is a cytoplasm protein which belongs to thecalycin superfamily and Fatty-acid bindi...
TMPY-03497	AKR1C2 Protein, Human, Recombinant (His)	Human	E. coli
	AKR1C2 is a member of the aldo/keto reductase superfamily, which consists of more than 4 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using ...
TMPJ-00715	FGF-19 Protein, Human, Recombinant (His)	Human	E. coli
	Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 dis...
TMPY-04813	ACAT2 Protein, Rat, Recombinant (His)	Rat	E. coli
	Acyl-coenzyme A: cholesterol acyltransferase (ACAT) is an intracellular enzyme that produces cholesteryl esters in various tissues. In mammals, two ACAT genes (ACAT1 and ACAT2) have been identified. Together, these two e...